No abstract available
Keywords:
Checkpoint inhibitor; Metastatic colorectal cancer; Microsatellite stable; Mismatch repair proficient; Tumor mutational burden.
MeSH terms
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Adenocarcinoma / drug therapy
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Adenocarcinoma / genetics
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Adenocarcinoma / pathology
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Antibodies, Monoclonal, Humanized / therapeutic use*
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Antineoplastic Agents, Immunological / therapeutic use
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Biomarkers, Tumor / genetics*
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Colorectal Neoplasms / drug therapy*
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Colorectal Neoplasms / genetics
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Colorectal Neoplasms / pathology
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DNA Mutational Analysis
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DNA-Binding Proteins / genetics
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Drug Resistance, Neoplasm / drug effects*
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High-Throughput Nucleotide Sequencing
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Humans
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Male
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Microsatellite Instability*
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Middle Aged
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Mutation*
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Prognosis
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Programmed Cell Death 1 Receptor / antagonists & inhibitors*
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Transcription Factors / genetics
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Transforming Growth Factor beta1 / genetics
Substances
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ARID1A protein, human
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Antibodies, Monoclonal, Humanized
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Antineoplastic Agents, Immunological
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Biomarkers, Tumor
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DNA-Binding Proteins
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G-T mismatch-binding protein
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PDCD1 protein, human
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Programmed Cell Death 1 Receptor
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TGFB1 protein, human
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Transcription Factors
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Transforming Growth Factor beta1
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pembrolizumab