Efficacy of PD-1 Blockade in Refractory Microsatellite-Stable Colorectal Cancer With High Tumor Mutation Burden

Clin Colorectal Cancer. 2019 Dec;18(4):307-309. doi: 10.1016/j.clcc.2019.08.001. Epub 2019 Sep 4.
No abstract available

Keywords: Checkpoint inhibitor; Metastatic colorectal cancer; Microsatellite stable; Mismatch repair proficient; Tumor mutational burden.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / drug therapy
  • Adenocarcinoma / genetics
  • Adenocarcinoma / pathology
  • Antibodies, Monoclonal, Humanized / therapeutic use*
  • Antineoplastic Agents, Immunological / therapeutic use
  • Biomarkers, Tumor / genetics*
  • Colorectal Neoplasms / drug therapy*
  • Colorectal Neoplasms / genetics
  • Colorectal Neoplasms / pathology
  • DNA Mutational Analysis
  • DNA-Binding Proteins / genetics
  • Drug Resistance, Neoplasm / drug effects*
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Male
  • Microsatellite Instability*
  • Middle Aged
  • Mutation*
  • Prognosis
  • Programmed Cell Death 1 Receptor / antagonists & inhibitors*
  • Transcription Factors / genetics
  • Transforming Growth Factor beta1 / genetics

Substances

  • ARID1A protein, human
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents, Immunological
  • Biomarkers, Tumor
  • DNA-Binding Proteins
  • G-T mismatch-binding protein
  • PDCD1 protein, human
  • Programmed Cell Death 1 Receptor
  • TGFB1 protein, human
  • Transcription Factors
  • Transforming Growth Factor beta1
  • pembrolizumab