Unlocking Nanocarriers for the Programmed Release of Antimalarial Drugs

Amir Reza Bagheri; Seema Agarwal; Jacob Golenser; Andreas Greiner

doi:10.1002/gch2.201600011

Unlocking Nanocarriers for the Programmed Release of Antimalarial Drugs

Glob Chall. 2017 Jan 30;1(2):1600011. doi: 10.1002/gch2.201600011. eCollection 2017 Feb 27.

Authors

Amir Reza Bagheri¹, Seema Agarwal¹, Jacob Golenser², Andreas Greiner¹

Affiliations

¹ Macromolecular Chemistry Bavarian Polymer Institute University of Bayreuth Universitätsstraße 30 95440 Bayreuth Germany.
² Department of Microbiology and Molecular Genetics The Kuvin Centre for the Study of Infectious and Tropical Diseases The Hebrew University of Jerusalem 91120 Jerusalem Israel.

Abstract

A programmable release system with wide range of release profiles of the antimalarial artemisone (ART) from fibrous nanocarriers (NFN) is presented. This is achieved following a new paradigm of using ART-loaded NFN in infusion system of hydrophobic drug eluting nanocarriers, adapted to clinical applications. Very importantly, under these conditions ART did not degrade as it was observed in solution.

Keywords: drug carrier; electrospinning; malaria; programmed drug release.