GWAS Atlas: a curated resource of genome-wide variant-trait associations in plants and animals

Dongmei Tian; Pei Wang; Bixia Tang; Xufei Teng; Cuiping Li; Xiaonan Liu; Dong Zou; Shuhui Song; Zhang Zhang

doi:10.1093/nar/gkz828

GWAS Atlas: a curated resource of genome-wide variant-trait associations in plants and animals

Nucleic Acids Res. 2020 Jan 8;48(D1):D927-D932. doi: 10.1093/nar/gkz828.

Authors

Dongmei Tian^{1

2}, Pei Wang^{1

2

3}, Bixia Tang^{1

2}, Xufei Teng^{1

2

3}, Cuiping Li^{1

2}, Xiaonan Liu^{1

2

4}, Dong Zou^{1

2}, Shuhui Song^{1

2

3

5}, Zhang Zhang^{1

2

3

4

5}

Affiliations

¹ National Genomics Data Center, Beijing 100101, China.
² BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
³ College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
⁴ School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China.
⁵ CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.

Abstract

GWAS Atlas (https://bigd.big.ac.cn/gwas/) is a manually curated resource of genome-wide variant-trait associations for a wide range of species. Unlike existing related resources, it features comprehensive integration of a high-quality collection of 75 467 variant-trait associations for 614 traits across 7 cultivated plants (cotton, Japanese apricot, maize, rapeseed, rice, sorghum and soybean) and two domesticated animals (goat and pig), which were manually curated from 254 publications. We integrated these associations into GWAS Atlas and presented them in terms of variants, genes, traits, studies and publications. More importantly, all associations and traits were annotated and organized based on a suite of ontologies (Plant Trait Ontology, Animal Trait Ontology for Livestock, etc.). Taken together, GWAS Atlas integrates high-quality curated GWAS associations for animals and plants and provides user-friendly web interfaces for data browsing and downloading, accordingly serving as a valuable resource for genetic research of important traits and breeding application.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Databases, Genetic*
Genetic Variation*
Genome-Wide Association Study* / methods
Genomics* / methods
Plants / genetics
Quantitative Trait Loci*
Quantitative Trait, Heritable*
Software
User-Computer Interface
Web Browser