Abstract
Here, we have compared the behavioral neurotoxicity of a manganese nanoformulation (citrate functionalized Mn3O4 nanoparticles; C-Mn3O4 NPs) with that of the well-known neurotoxicant, ionic Mn, in an animal model. We found that mice administered with C-Mn3O4 NPs showed no signs of a neurobehavioral disorder, but the NPs instead ameliorated Mn-induced neurotoxicity (Parkinson's-like syndrome) through the chelation of excess Mn ions and subsequent reduction of oxidative damage.
MeSH terms
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Animals
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Behavior, Animal / drug effects*
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Disease Models, Animal*
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Hippocampus / drug effects*
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Hippocampus / metabolism
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Hippocampus / pathology
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Manganese Compounds / administration & dosage
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Mitochondria / drug effects
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Mitochondria / metabolism
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Nanoparticles / administration & dosage
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Nanoparticles / toxicity*
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Neurons / drug effects*
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Neurons / metabolism
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Neurons / pathology
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Oxidation-Reduction
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Oxides / administration & dosage
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Oxides / toxicity*
Substances
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Manganese Compounds
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Oxides
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manganese oxide