Cross-reactivity in beta-lactams after a non-immediate cutaneous adverse reaction: experience of a reference centre for toxic bullous diseases and severe cutaneous adverse reactions

J Eur Acad Dermatol Venereol. 2020 Apr;34(4):787-794. doi: 10.1111/jdv.15986. Epub 2019 Oct 28.

Abstract

Background: Cross-reactivity among beta-lactam antibiotics (BL) is essentially reported in immediate hypersensitivity.

Objectives: To evaluate cross-reactivity beyond BLs in patients with non-immediate cutaneous adverse drug reaction (non-immediate CADR) managed in a dermatology reference centre of toxic bullous and severe CADRs.

Patients/materials/methods: We conducted a retrospective single-centre study in consecutive patients consulting between 2010 and 2018 with an active BL-suspected non-immediate CADR and explored by cutaneous tests [patch tests (PT) and intradermal tests (P-IDR)] for at least three penicillin's subclasses and amino- and non-amino-cephalosporins (at least one aminocephalosporin). Cross-reactivity among subclasses was investigated for patients with positive tests.

Results: We included 56 patients, among whom 46 amoxicillin-suspected were and seven cephalosporin-suspected. Twenty-nine had severe CADR, and 27 had non-immediate maculopapular exanthema (MPE). Twenty-two had positive tests (18 for AS and four for CS). Among the 18 positive amoxicillin-suspected, 10 (55.6%) showed cross-reactivity with one or more other BL: 9 (50%) with another penicillin and 3 (16.5%) with a non-aminocephalosporin. No amoxicillin- or cephalosporin-suspected patient showed cross-reactivity with aztreonam or carbapenems. P-IDR showed cross-reactivity only once.

Conclusion: After a suspected BL-induced non-immediate CADR, a large allergologic exploration is needed to confirm the diagnosis and evaluate cross-reactivity. In our population including cases of severe CADRs and MPE with late delay of onset, cross-reactivity was frequent and PT was sufficient to this purpose. The frequent cross-reactivity among penicillins encourages stopping this whole family and to test cephalosporins, aztreonam and carbapenems for which cross-allergies are rarer.

MeSH terms

  • Adult
  • Aged
  • Cephalosporins / adverse effects
  • Cross Reactions
  • Drug Eruptions*
  • Drug Hypersensitivity
  • Female
  • Humans
  • Male
  • Middle Aged
  • Penicillins / adverse effects
  • Retrospective Studies
  • Risk Factors
  • Skin Tests
  • beta-Lactams / adverse effects*

Substances

  • Cephalosporins
  • Penicillins
  • beta-Lactams