Case report: Paradoxical responses to short acting beta-agonists in a pediatric patient

J Asthma. 2021 Feb;58(2):213-215. doi: 10.1080/02770903.2019.1668009. Epub 2019 Oct 1.

Abstract

Introduction: Asthma is one of the most common airway diseases that nearly all pediatricians will encounter in their clinical practice. Using spirometry to compare a patient's forced expiratory volume in one second (FEV1) both pre- and post-bronchodilator administration is the ideal way to document a paradoxical bronchodilator response.Case Study: Here, we present a patient who experienced paradoxical responses to short acting beta-2 agonists (SABAs; albuterol and levalbuterol).Results: This patient responded to an anti-cholinergic agent (ipratropium bromide) with both subjective as well as objective response.Conclusion: This case highlights the need to include paradoxical response to SABAs in the differential of a patient with poorly controlled asthma. It also provides an example of successful treatment of a pediatric patient with a class of medications previously reserved for adults with chronic obstructive pulmonary disease.

Keywords: Case Reports; Pediatrics; Treatment.

Publication types

  • Case Reports

MeSH terms

  • Adrenergic beta-2 Receptor Agonists / adverse effects*
  • Adrenergic beta-2 Receptor Agonists / therapeutic use
  • Albuterol / adverse effects*
  • Albuterol / therapeutic use
  • Asthma / drug therapy*
  • Bronchodilator Agents / administration & dosage
  • Bronchodilator Agents / adverse effects
  • Bronchodilator Agents / therapeutic use*
  • Child
  • Female
  • Humans
  • Ipratropium / therapeutic use
  • Levalbuterol / adverse effects*
  • Levalbuterol / therapeutic use

Substances

  • Adrenergic beta-2 Receptor Agonists
  • Bronchodilator Agents
  • Levalbuterol
  • Ipratropium
  • Albuterol