The stromal microenvironment provides an escape route from FLT3 inhibitors through the GAS6-AXL-STAT5 axis

Haematologica. 2019 Oct;104(10):1907-1909. doi: 10.3324/haematol.2019.225862.
No abstract available

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Benzothiazoles
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Hypoxia
  • Leukemia, Myeloid, Acute*
  • Phenylurea Compounds
  • STAT5 Transcription Factor
  • Tumor Microenvironment
  • Up-Regulation
  • fms-Like Tyrosine Kinase 3

Substances

  • Benzothiazoles
  • Phenylurea Compounds
  • STAT5 Transcription Factor
  • quizartinib
  • FLT3 protein, human
  • fms-Like Tyrosine Kinase 3