Selective Hydrogenation by Carbocatalyst: The Role of Radicals

Org Lett. 2019 Oct 18;21(20):8164-8168. doi: 10.1021/acs.orglett.9b02432. Epub 2019 Oct 4.

Abstract

The selective hydrogenation of the nitro moiety is a difficult task in the presence of other reducible functional groups such as alkenes or alkynes. We show that the carbon-based (metal-free) catalyst can be used to selectively reduce substituted nitro groups using H2 as a reducing agent, providing a great potential to replace noble-metal catalysts and contributing to simple and greener strategies for organic synthesis.