Abstract
A novel type of hydrogen peroxide (H2O2)-activated diazeniumdiolate based on an α-ketoamide moietey was developed as a nitric oxide (NO) donor. KA-NO-4 inhibited lung cancer cells with submicromolar activity. The H2O2-responsive behaviour of KA-NO-4 was thoroughly investigated. The NO-centered mechanism of action of KA-NO-4 was intracellularly studied.
MeSH terms
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Amides / chemistry*
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Apoptosis / drug effects
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Azo Compounds / chemistry*
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Azo Compounds / pharmacology
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Cell Line, Tumor
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Cell Movement / drug effects
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Humans
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Hydrogen Peroxide / chemistry*
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Lung Neoplasms / metabolism
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Lung Neoplasms / pathology
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Nitric Oxide / metabolism
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Nitric Oxide Donors / chemistry*
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Nitric Oxide Donors / pharmacology
Substances
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Amides
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Antineoplastic Agents
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Azo Compounds
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Nitric Oxide Donors
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diazeniumdiolate
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Nitric Oxide
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Hydrogen Peroxide