Going in Circles: The Black Box of Circular RNA Immunogenicity

Megha G Basavappa; Sara Cherry

doi:10.1016/j.molcel.2019.08.027

Going in Circles: The Black Box of Circular RNA Immunogenicity

Mol Cell. 2019 Oct 3;76(1):3-5. doi: 10.1016/j.molcel.2019.08.027.

Authors

Megha G Basavappa¹, Sara Cherry²

Affiliations

¹ Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
² Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: [email protected].

PMID: 31585102
DOI: 10.1016/j.molcel.2019.08.027

Abstract

Two recent papers in Molecular Cell (Chen et al., 2019; Wesselhoeft et al., 2019) have probed the putative immunogenicity of circular RNAs (circRNAs). These studies indicate that the stimulatory capacity of circRNAs depends on factors including the specific RNA, the mode of biogenesis, RNA modifications, cell type, and the means of delivery.

Publication types

Comment

MeSH terms

Adenosine / analogs & derivatives
RNA Splicing
RNA*
RNA, Circular*

Substances

RNA, Circular
RNA
N-methyladenosine
Adenosine