Impact of vitamin D supplementation model on the circulating levels of 25 (OH) D in Algerian children aged 1-23 months

J Steroid Biochem Mol Biol. 2020 Feb:196:105487. doi: 10.1016/j.jsbmb.2019.105487. Epub 2019 Oct 3.

Abstract

Vitamin D deficiency is a public health problem around the world. In Algeria, the nutritional situation is still subject to uncertainties. In order to evaluate the vitamin D status and to know the impact of the current vitamin D supplementation model on the circulating levels of 25 (OH) D, an investigation was conducted on a group of Algerian children. The study was conducted in the Blida region (Northern Algeria). Sampling focused on 150 healthy children, aged between 1 and 23 months old, recruited from Ben Boulaïd hospital pediatric ward. 83% of children (n = 125) have been supplemented with vitamin D (D3 B.O.N®) according to a scheme currently designed in Algeria (the first intake of 200 000 IU at 1 month and the second intake of 200 000 IU at 6 months). 17% of children (n = 25) have escaped from a supplementation. The average values of 25(OH) D are respectively: 51 ± 20 μg/L for 103 supplement children with vitamin D (25 (OH)D ≤ 100 μg/L), 222 ± 106 μg/L for 22 supplement children with vitamin D (25(OH) D > 100 μg/L) and 30 ± 16 μg/L for 25 non-supplement children with vitamin D. The prevalence of vitamin D deficiency is lower (4%) among the children group with vitamin D supplement. These results show that the vitamin D supplementation model seems entirely efficient on the improvement of vitamin D status.

Keywords: 25-hydroxyvitamin D; Algeria; Pediatrics; Vitamin D status; Vitamin D supplementation.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algeria / epidemiology
  • Calcifediol / blood*
  • Chemoprevention
  • Dietary Supplements
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Treatment Outcome
  • Vitamin D / administration & dosage*
  • Vitamin D / blood
  • Vitamin D Deficiency / blood*
  • Vitamin D Deficiency / epidemiology
  • Vitamin D Deficiency / prevention & control*

Substances

  • Vitamin D
  • Calcifediol