Combined ipilimumab and nivolumab first-line and after BRAF-targeted therapy in advanced melanoma

Pigment Cell Melanoma Res. 2020 Mar;33(2):358-365. doi: 10.1111/pcmr.12831. Epub 2019 Nov 2.

Abstract

The combination of ipilimumab and nivolumab is a highly active systemic therapy for metastatic melanoma but can cause significant toxicity. We explore the safety and efficacy of this treatment in routine clinical practice, particularly in the setting of serine/threonine-protein kinase B-Raf (BRAF)-targeted therapy. Consecutive patients with unresectable stage IIIC/IV melanoma commenced on ipilimumab and nivolumab across 10 tertiary melanoma institutions in Australia were identified retrospectively. Data collected included demographics, response and survival outcomes. A total of 152 patients were included for analysis, 39% were treatment-naïve and 22% failed first-line BRAF/MEK inhibitors. Treatment-related adverse events occurred in 67% of patients, grade 3-5 in 38%. The overall objective response rate was 41%, 57% in treatment-naïve and 21% in BRAF/MEK failure patients. Median progression-free survival was 4.0 months (95% CI, 3.0-6.0) in the whole cohort, 11.0 months (95% CI, 6.0-NR) in treatment-naïve and 2.0 months (95% CI, 1.4-4.6) in BRAF/MEK failure patients. The combination of ipilimumab and nivolumab can be used safely and effectively in a real-world population. While first-line efficacy appears comparable to trial populations, BRAF-mutant patients failing prior BRAF/MEK inhibitors show less response.

Keywords: BRAF; immunotherapy; ipilimumab; melanoma; nivolumab; targeted therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / pharmacology
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Disease-Free Survival
  • Female
  • Humans
  • Ipilimumab / adverse effects
  • Ipilimumab / pharmacology
  • Ipilimumab / therapeutic use*
  • Male
  • Melanoma
  • Middle Aged
  • Molecular Targeted Therapy*
  • Neoplasm Staging
  • Nivolumab / adverse effects
  • Nivolumab / pharmacology
  • Nivolumab / therapeutic use*
  • Proto-Oncogene Proteins B-raf / antagonists & inhibitors*
  • Proto-Oncogene Proteins B-raf / metabolism
  • Skin Neoplasms
  • Treatment Outcome
  • Young Adult

Substances

  • Ipilimumab
  • Nivolumab
  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf