Divergent pathway and reactivity control of intramolecular arene C-H vinylation by vinyl cations

Org Biomol Chem. 2019 Oct 23;17(41):9135-9139. doi: 10.1039/c9ob01916b.

Abstract

Vinyl cations exhibit remarkable reactivity towards arene C-H functionalizations. This computational study revealed the key mechanistic details of intramolecular C-H vinylation through a vinyl cation intermediate. Based on the reaction mechanism, the effects of substitution, ring strain and tether length on the reactivity of the vinyl cation were elucidated.

Publication types

  • Research Support, Non-U.S. Gov't