HLA-B*15:47:01 allele with undefined serological equivalent considered as B Blank

Judith Desoutter; Valentine Jacob; Nicolas Guillaume

doi:10.1111/iji.12457

HLA-B*15:47:01 allele with undefined serological equivalent considered as B Blank

Int J Immunogenet. 2020 Feb;47(1):65-66. doi: 10.1111/iji.12457. Epub 2019 Oct 9.

Authors

Judith Desoutter^{1

2}, Valentine Jacob^{1

2}, Nicolas Guillaume^{1

2}

Affiliations

¹ Department of Histocompatibility, Amiens University Medical Center, Amiens, France.
² EA 4666 HEMATIM, Jules Verne University of Picardie, Amiens, France.

PMID: 31599086
DOI: 10.1111/iji.12457

Abstract

We report a discordance between complement-dependent cytotoxicity and next-generation sequencing molecular typing revealing HLA-B*15:47:01 allele with undefined serological equivalent confirmed by high-level immunization against the B15 serotype. Due to the high-level immunization against HLA-B15 and B70 antigens, we considered the HLA-B*15:47:01 allele to be B Blank and not as B15 or B70 serological specificity.

Keywords: HLA; allele frequencies; expression; genetics; histocompatibility; medicine; molecular; transplantation.

Publication types

Case Reports

MeSH terms

Alleles
B7-2 Antigen / immunology
Complement System Proteins / metabolism
Cytotoxicity, Immunologic
Genes, MHC Class I / genetics*
HLA-B15 Antigen / genetics*
HLA-B15 Antigen / immunology*
High-Throughput Nucleotide Sequencing
Histocompatibility Testing
Humans
Male
Middle Aged

Substances

B7-2 Antigen
CD86 protein, human
HLA-B15 Antigen
Complement System Proteins