Antioxidative, protein kinase inhibition and antibacterial potential of seven mango varieties cultivated in Pakistan

Pak J Pharm Sci. 2019 Jul;32(4):1687-1695.

Abstract

Peel, pulp and kernel extracts of seven mango fruit (varieties) were analyzedsubjected for antibacterial and antioxidative potential. Langra peel showed good activity against B. subtilis, S. aureus and E. aerogenes. Good zone of inhibition by chaunsa kernel (28mm) and pulp (22mm) against Streptomyces stipulate its potential as anticarcinogencancerous. Dosehri and almashil pulp and sindhri peel asserted free radical scavenger (upto 79%) determined through DPPH assay. The peel and kernel of almashil contained maximum (total) flavonoids contents (58 & 43μgQE/100mg, respectively) while; total phenolics were higher in kernel of sindhri, chaunsa, langra and hujra and almashil pulp. Reducing power potential demonstrated variation from 300 to 554μgAAE/100mg. Total antioxidant potential was maximum in hujra pulp (512μg AAE/100mg). Concluded This study concludes that mango has vast beneficial potential for prone to human health and may also be used for isolation of antioxidative and antimicrobial as well as a protein kinase inhibition agent.

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Biphenyl Compounds
  • Drug Evaluation, Preclinical
  • Free Radical Scavengers / chemistry
  • Free Radical Scavengers / pharmacology
  • Fruit / chemistry
  • Mangifera / chemistry*
  • Microbial Sensitivity Tests
  • Pakistan
  • Phenols / analysis
  • Picrates
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Protein Kinase Inhibitors / chemistry
  • Protein Kinase Inhibitors / pharmacology*
  • Seeds / chemistry
  • Species Specificity
  • Streptomyces / drug effects

Substances

  • Anti-Bacterial Agents
  • Antioxidants
  • Biphenyl Compounds
  • Free Radical Scavengers
  • Phenols
  • Picrates
  • Plant Extracts
  • Protein Kinase Inhibitors
  • 1,1-diphenyl-2-picrylhydrazyl