Contribution of Fcγ receptor IIB to creating a suppressive tumor microenvironment in a mouse model

Cancer Immunol Immunother. 2019 Nov;68(11):1769-1778. doi: 10.1007/s00262-019-02413-w. Epub 2019 Oct 15.

Abstract

Various immune cells are recruited in the tumor microenvironment. It is well established that cellular immune responses, such as cytotoxic or suppressive activities, play an important role in regulating tumor growth and metastasis. However, the contribution of humoral immune responses against tumors is poorly understood. Fc receptors constitute critical elements for the up- or downregulation of immune responses through immune complexes. Here, we examined the potential role of the inhibitory Fc receptor, Fcγ receptor IIB (FcγRIIB), in tumor immunity using a mouse model. Our findings indicated that tumor-specific antibodies are induced in tumor-bearing mice and control tumor immunity. FcγRIIB deletion significantly improved both cellular and humoral immunity against tumors and delayed tumor growth. These findings indicated that spontaneous antibodies against tumors create a suppressive tumor microenvironment through FcγRIIB signaling, thus suggesting an attractive therapeutic target for cancer immunotherapy.

Keywords: Antibody; Fc receptors; Macrophages; Mouse model; Tumor microenvironment.

MeSH terms

  • Animals
  • Antibodies / immunology*
  • Carcinoma, Lewis Lung / immunology
  • Carcinoma, Lewis Lung / metabolism
  • Carcinoma, Lewis Lung / pathology
  • Carcinoma, Lewis Lung / therapy*
  • Disease Models, Animal
  • Female
  • Immunotherapy*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Receptors, IgG / immunology
  • Receptors, IgG / physiology*
  • Thymoma / immunology
  • Thymoma / metabolism
  • Thymoma / pathology
  • Thymoma / therapy*
  • Thymus Neoplasms / immunology
  • Thymus Neoplasms / metabolism
  • Thymus Neoplasms / pathology
  • Thymus Neoplasms / therapy*
  • Tumor Cells, Cultured
  • Tumor Microenvironment / immunology*
  • Xenograft Model Antitumor Assays

Substances

  • Antibodies
  • Fc gamma receptor IIB
  • Receptors, IgG

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