Physical and chemical profiles of nanoparticles for lymphatic targeting

Xiyu Ke; Gregory P Howard; Haoyu Tang; Bei Cheng; May Tun Saung; José L Santos; Hai-Quan Mao

doi:10.1016/j.addr.2019.09.005

Physical and chemical profiles of nanoparticles for lymphatic targeting

Adv Drug Deliv Rev. 2019 Nov-Dec:151-152:72-93. doi: 10.1016/j.addr.2019.09.005. Epub 2019 Oct 15.

Authors

Xiyu Ke¹, Gregory P Howard², Haoyu Tang³, Bei Cheng⁴, May Tun Saung⁵, José L Santos⁶, Hai-Quan Mao⁷

Affiliations

¹ Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
² Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
³ Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.
⁴ Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
⁵ Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
⁶ Dosage Form Design & Development, AstraZeneca, Gaithersburg, MD 20878, USA. Electronic address: [email protected].
⁷ Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: [email protected].

PMID: 31626825
DOI: 10.1016/j.addr.2019.09.005

Abstract

Nanoparticles (NPs) have been gaining prominence as delivery vehicles for modulating immune responses to improve treatments against cancer and autoimmune diseases, enhancing tissue regeneration capacity, and potentiating vaccination efficacy. Various engineering approaches have been extensively explored to control the NP physical and chemical properties including particle size, shape, surface charge, hydrophobicity, rigidity and surface targeting ligands to modulate immune responses. This review examines a specific set of physical and chemical characteristics of NPs that enable efficient delivery targeted to secondary lymphoid tissues, specifically the lymph nodes and immune cells. A critical analysis of the structure-property-function relationship will facilitate further efforts to engineer new NPs with unique functionalities, identify novel utilities, and improve the clinical translation of NP formulations for immunotherapy.

Keywords: Immune cells; Immunotherapy; Lymph node; Nanoparticles; Physicochemical properties; Vaccine.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Dendritic Cells / drug effects*
Dendritic Cells / immunology
Drug Delivery Systems
Humans
Hydrophobic and Hydrophilic Interactions
Lymph Nodes / drug effects*
Lymph Nodes / immunology
Nanoparticles / chemistry*
Particle Size
Surface Properties

Grants and funding

R01 AI114609/AI/NIAID NIH HHS/United States