Streptococcus pyogenes pbp2x Mutation Confers Reduced Susceptibility to β-Lactam Antibiotics

Kirsten S Vannice; Jessica Ricaldi; Srinivas Nanduri; Ferric C Fang; John B Lynch; Chloe Bryson-Cahn; Theodore Wright; Jeff Duchin; Meagan Kay; Sopio Chochua; Chris A Van Beneden; Bernard Beall

doi:10.1093/cid/ciz1000

Streptococcus pyogenes pbp2x Mutation Confers Reduced Susceptibility to β-Lactam Antibiotics

Clin Infect Dis. 2020 Jun 24;71(1):201-204. doi: 10.1093/cid/ciz1000.

Authors

Affiliations

¹ Epidemiology Workforce Branch, Division of Scientific Education and Professional Development, Epidemic Intelligence Service, Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
² Communicable Disease Epidemiology and Immunization, Prevention Division, Public Health-Seattle & King County, Seattle, Washington, USA.
³ Respiratory Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
⁴ Harborview Medical Center, Seattle, Washington, USA.

Abstract

Two near-identical clinical Streptococcus pyogenes isolates of emm subtype emm43.4 with a pbp2x missense mutation (T553K) were detected. Minimum inhibitory concentrations (MICs) for ampicillin and amoxicillin were 8-fold higher, and the MIC for cefotaxime was 3-fold higher than for near-isogenic control isolates, consistent with a first step in developing β-lactam resistance.

Keywords: antimicrobial resistance; group A Streptococcus; β-lactam resistance.

Published by Oxford University Press for the Infectious Diseases Society of America 2019.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Anti-Bacterial Agents / pharmacology
Humans
Microbial Sensitivity Tests
Mutation
Penicillin-Binding Proteins / genetics
Streptococcus pyogenes* / genetics
beta-Lactam Resistance* / genetics

Substances

Anti-Bacterial Agents
Penicillin-Binding Proteins

Grants and funding

CC999999/ImCDC/Intramural CDC HHS/United States