Size- and Morphology-Controlled Preparation of Surface-Modified Water-Dispersible Fullerene Nanoparticles for Bioapplications

Hidetoshi Oguma; Eri Seitoku; Mami Mutoh; Saori Yoshizawa; Ko Nakanishi; Yosuke Bando; Yuko Era; Takayuki Kiba; Pipop Saikaew; Miho Tamai; Tsukasa Akasaka; Mariko Nakamura; Teruo Kusaka; Yasuhiro Yoshida; Yoshiaki Sato; Hidehiko Sano; Shigeaki Abe; Valanezhad Alireza; Ikuya Watanabe; Satoshi Inoue; Tomoya Takada

doi:10.1166/jnn.2020.17473

Size- and Morphology-Controlled Preparation of Surface-Modified Water-Dispersible Fullerene Nanoparticles for Bioapplications

J Nanosci Nanotechnol. 2020 May 1;20(5):2668-2674. doi: 10.1166/jnn.2020.17473.

Authors

Hidetoshi Oguma¹, Eri Seitoku¹, Mami Mutoh¹, Saori Yoshizawa¹, Ko Nakanishi¹, Yosuke Bando¹, Yuko Era¹, Takayuki Kiba², Pipop Saikaew³, Miho Tamai¹, Tsukasa Akasaka¹, Mariko Nakamura⁴, Teruo Kusaka¹, Yasuhiro Yoshida¹, Yoshiaki Sato¹, Hidehiko Sano¹, Shigeaki Abe¹, Valanezhad Alireza⁵, Ikuya Watanabe⁵, Satoshi Inoue¹, Tomoya Takada⁶

Affiliations

¹ Faculty of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan.
² Department of Materials Science and Engineering, Kitami Institute of Technology, Kitami 080-8507, Japan.
³ Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand.
⁴ School of Health Science, Kyushu University of Health and Welfare, Nobeoka 882-8508, Japan.
⁵ Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto 1-7-1, Nagasaki 852-8102, Japan.
⁶ Department of Applied Chemistry and Bioscience, Chitose Institute of Science and Technology, Chitose 066-8655, Japan.

PMID: 31635601
DOI: 10.1166/jnn.2020.17473

Abstract

In this study, we investigated water-dispersible surface modification for size- and shape-controlled fullerene nanoparticles (C₆₀P) based on a condensation reaction with di-amino alkane. This modification provided for water dispersibility of C₆₀P and the capability for secondary modification as well. The resultant C₆₀P particles have several useful physical properties: water-dispersibility for ease of injection; fluorescence for detection and quantification; and a characteristic morphology to assist identification. These properties will widely extend the applications of these particles, especially into the biological fields of bioimaging and drug delivery.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Fullerenes*
Nanoparticles*
Water

Substances

Fullerenes
Water