Fantastic beasts and how to find them-Molecular identification of the mitochondrial ATP-sensitive potassium channel

Sean M Davidson; Gyorgy Szabadkai; Michael R Duchen

doi:10.1016/j.ceca.2019.102100

Fantastic beasts and how to find them-Molecular identification of the mitochondrial ATP-sensitive potassium channel

Cell Calcium. 2019 Dec:84:102100. doi: 10.1016/j.ceca.2019.102100. Epub 2019 Oct 15.

Authors

Sean M Davidson¹, Gyorgy Szabadkai², Michael R Duchen³

Affiliations

¹ The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, WC1E 6HX, United Kingdom.
² Department of Cell and Developmental Biology and UCL Consortium for Mitochondrial Research, University College London, Gower Street, London, WC1E 6BT, United Kingdom; Department of Biomedical Sciences, University of Padua, Padua, Italy.
³ Department of Cell and Developmental Biology and UCL Consortium for Mitochondrial Research, University College London, Gower Street, London, WC1E 6BT, United Kingdom. Electronic address: [email protected].

PMID: 31639649
DOI: 10.1016/j.ceca.2019.102100

Abstract

Despite reported sightings over many years, certain mitochondrial-specific channels have proven to be elusive beasts, evading molecular identification. However, combining modern genetics with a wave of their ion-sensing wand, researchers have managed to capture first the mitochondrial calcium uniporter, and now that semi-mythological beast, the mitochondrial ATP-sensitive potassium (mitoK_ATP) channel.

Keywords: Ischaemia and reperfusion; Katp channel; Mitochondria.

MeSH terms

Adenosine Triphosphate / metabolism
Animals
Humans
KATP Channels / genetics
KATP Channels / metabolism*
Mitochondria / metabolism*
Potassium / metabolism*
Potassium Channel Blockers / pharmacology
Reperfusion Injury / metabolism*

Substances

KATP Channels
Potassium Channel Blockers
Adenosine Triphosphate
Potassium