Abstract
In this review, the effects of stress on alcohol drinking are discussed. The interactions between biological stress systems and alcohol drinking are examined, with a focus on the hypothalamic pituitary adrenal axis, corticotropin releasing factor, dynorphin, neuropeptide Y, and norepinephrine systems. Findings from animal models suggest that these biological stress systems may be useful targets for medications development for alcohol use disorder and co-occurring stress-related disorders in humans.
Keywords:
alcohol; animal models; stress.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Alcohol Drinking / epidemiology*
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Alcohol Drinking / physiopathology
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Animals
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Comorbidity
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Corticotropin-Releasing Hormone / physiology
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Dynorphins / physiology
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Humans
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Hypothalamo-Hypophyseal System / physiopathology
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Neuropeptide Y / physiology
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Norepinephrine / physiology
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Pituitary-Adrenal System / physiopathology
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Stress, Psychological / epidemiology*
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Stress, Psychological / physiopathology
Substances
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Neuropeptide Y
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Dynorphins
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Corticotropin-Releasing Hormone
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Norepinephrine