Immune checkpoint inhibitors (ICIs) have made remarkable breakthroughs in cancer treatment. However, the widely use of ICIs is associated with a spectrum of immune-related adverse events (irAEs). These adverse events can affect any organ system. In this article, we have made a systemic review about the clinical characteristics of rheumatic irAEs, and also summarized irAEs in patients with pre-exsiting rheumatic disease. We also focus on the management of rheumatic irAEs.
【中文题目：免疫检查点抑制剂风湿性毒副反应诊治建议】 【中文摘要：近年来，免疫检查点抑制剂（immune checkpoint inhibitors, ICIs）已成为肿瘤治疗的突破性进展之一。但随着ICIs的广泛应用，这类药物所导致的免疫相关副反应（immune-related adverse events, irAEs）也逐渐引起人们的重视。研究发现，irAEs几乎可影响到人体的各个器官。本文主要针对ICIs在风湿方面毒副反应的临床特点展开综述，并且总结了具有基础风湿病的患者在使用ICIs后的免疫相关副反应，最后对这类副反应的治疗进行了探讨。】 【中文关键词：免疫检查点抑制剂；免疫相关副反应；风湿性疾病；治疗】.
Keywords: Immune checkpoint inhibitors; Immune-related adverse events; Rheumatic disease; Treatment.