Abstract
In this study, we constructed bioconjugates of targeting immune checkpoint B7-H3 antibody and chlorin e6 to treat non-small cell lung cancer under the guidance of spectroscopic photoacoustic and fluorescence imaging. The B7-H3-Ce6 conjugates could display effective tumor diagnosis and therapy and provide a novel approach for immunotherapy.
MeSH terms
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A549 Cells
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Animals
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Antibodies / chemistry
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Antibodies / immunology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / immunology
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Antineoplastic Agents / pharmacology*
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Carcinoma, Non-Small-Cell Lung / immunology
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Carcinoma, Non-Small-Cell Lung / therapy*
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Cell Survival / drug effects
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Chlorophyllides
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Humans
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Immunotherapy
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Lung Neoplasms / immunology
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Lung Neoplasms / therapy*
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Mice
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Mice, Nude
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Microscopy, Confocal
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Neoplasms, Experimental / immunology
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Neoplasms, Experimental / therapy
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Optical Imaging
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Photoacoustic Techniques
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Photochemotherapy*
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / immunology
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Photosensitizing Agents / pharmacology*
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Porphyrins / chemistry
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Porphyrins / immunology
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Porphyrins / pharmacology*
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Spectrophotometry, Ultraviolet
Substances
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Antibodies
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Antineoplastic Agents
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Chlorophyllides
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Photosensitizing Agents
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Porphyrins
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phytochlorin