The fungal microbiota from self-retained soil and tongue coating of 18 patients with precancerous lesions of upper gastrointestinal (PLUG) were sequenced. The diversity of α, β in and the structure of the microbial community were analyzed, and the association of them was quantified by using the Spearman rank correlation method. The richness index (1.67±2.79) and the diversity index (0.25±0.10) of the fungal microbiota from tongue coating of PLUG patients were significantly lower than those from soil (4.00±4.69; 0.99±0.18) (all P values<0.001). The relative abundance of 11 taxa from tongue coating of these PLUG patients was positively associated with that from soil (all P values<0.05).
对18例上消化道癌前病变患者的舌苔和其自留地土壤真菌测序，进行菌群α、β多样性及菌群结构分析，并采用Spearman秩相关分析两者之间的相关性。上消化道癌癌前病变（PLUG）患者舌苔真菌丰富度指数（1.67±2.79）、多样性指数（0.25±0.10）均低于自留地土壤的真菌丰富度指数（4.00±4.69）和多样性指数（0.99±0.18）（P值均<0.001）；PLUG患者舌苔中11个真菌分类单元的相对丰度与土壤存在正相关（P值均<0.05）。.
Keywords: Case-control studies; Fungi; Precancerous conditions; Soil; Tongue.