Abnormal genomic DNA methylation is an important epigenetic change in malignant tumors. Esophageal squamous cell cancer is one of common malignant tumors in our country. In this paper summarized and discussed the progress of genomic DNA methylation in the esophageal squamouscell cancer, including the level of genomic DNA methylation, frequent abnormally methylated genes, methylation markers and potential targets, etc. This paper might provide candidate biomarkers and targets for further studies on the mechanism of the tumorigenesis and development of the esophagealsquamouscell cancer, as well as for the clinical application of esophageal cancer.
基因组DNA甲基化异常是恶性肿瘤重要的表观遗传学改变。食管鳞癌是我国常见的恶性肿瘤之一，本文从全基因组DNA甲基化水平、高频甲基化异常改变基因、甲基化标志物和潜在靶点等方面，总结讨论了食管鳞癌中基因组DNA甲基化的研究进展，为深入研究其发生发展机制、以及为食管鳞癌的临床应用提供候选标志物和靶点。.
Keywords: Biomarkers; Esophageal neoplasms; Genome; Methylation.