Towards a System for Tracking Drug Delivery Using Frequency Excited Gold Nanoparticles

Nazanin Neshatvar; Rui Damaso; Nima Seifnaraghi; Andreas Demosthenous; Richard Bayford

doi:10.3390/s19214750

Towards a System for Tracking Drug Delivery Using Frequency Excited Gold Nanoparticles

Sensors (Basel). 2019 Nov 1;19(21):4750. doi: 10.3390/s19214750.

Authors

Nazanin Neshatvar¹, Rui Damaso^{2

3}, Nima Seifnaraghi⁴, Andreas Demosthenous⁵, Richard Bayford^{6

7}

Affiliations

¹ Department of Electronic and Electrical Engineering, University College London, Torrington Place, London WC1E 7JE, UK. [email protected].
² Department of Electronic and Electrical Engineering, University College London, Torrington Place, London WC1E 7JE, UK. [email protected].
³ Department of Natural Science, Middlesex University, The Burroughs, Hendon, London NW4 4BT, UK. [email protected].
⁴ Department of Natural Science, Middlesex University, The Burroughs, Hendon, London NW4 4BT, UK. [email protected].
⁵ Department of Electronic and Electrical Engineering, University College London, Torrington Place, London WC1E 7JE, UK. [email protected].
⁶ Department of Electronic and Electrical Engineering, University College London, Torrington Place, London WC1E 7JE, UK. [email protected].
⁷ Department of Natural Science, Middlesex University, The Burroughs, Hendon, London NW4 4BT, UK. [email protected].

Abstract

Nanoparticle-based drugs are rapidly evolving to treat different conditions and have considerable potential. A new system based on the combination of electrical impedance tomography (EIT) imaging and a power amplifier with a RF coil has been developed to study the effect of gold nanoparticles (AuNPs) when excited in the MHz frequency range. We show that samples including AuNPs have a temperature increase of 1-1.5 °C due to the presence of RF excitation at 13.56 MHz which provides a higher rate of change for solutions without AuNPs. They also show more than a 50% increase in conductivity in difference imaging as the result of this excitation. The change for samples without AuNPs is 40%.

Keywords: drug delivery; electrical impedance tomography (EIT); gold nanoparticles; power amplifier; radio frequency (RF) induction.

MeSH terms

Amplifiers, Electronic
Drug Delivery Systems*
Electric Impedance
Electrodes
Gold / chemistry*
Metal Nanoparticles / chemistry*
Radio Waves
Temperature
Tomography

Substances

Gold