No Amikacin, No Problem: a Successful Treatment Approach for Pediatric Otomastoiditis Due to Amikacin-Resistant Mycobacterium abscessus

Antimicrob Agents Chemother. 2019 Dec 20;64(1):e02023-19. doi: 10.1128/AAC.02023-19. Print 2019 Dec 20.

Abstract

Pediatric otomastoiditis due to Mycobacterium abscessus can be a devastating infection that presents multiple treatment challenges. Van Wijk et al. report the use of a structured approach with a standardized regimen of intravenous (i.v.), topical, and oral antibiotics and surgical intervention for four pediatric patients with multidrug-resistant Mycobacterium abscessus otomastoiditis. Despite treatment-related adverse events, all four patients achieved sustained cure with this approach. This case series provides a framework for managing drug-resistant Mycobacterium abscessus otomastoiditis.

Keywords: Mycobacterium abscessus; pediatric otomastoiditis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Amikacin
  • Anti-Bacterial Agents
  • Child
  • Humans
  • Microbial Sensitivity Tests
  • Mycobacterium Infections, Nontuberculous*
  • Mycobacterium abscessus*

Substances

  • Anti-Bacterial Agents
  • Amikacin