N-(2-hydroxyethyl)phenazinium derivatives of oligonucleotides as effectors of the sequence-specific modification of nucleic acids with reactive oligonucleotide derivatives

I V Kutyavin; M A Podyminogin; Bazhina YuN; O S Fedorova; D G Knorre; A S Levina; S V Mamayev; V F Zarytova

doi:10.1016/0014-5793(88)80220-5

N-(2-hydroxyethyl)phenazinium derivatives of oligonucleotides as effectors of the sequence-specific modification of nucleic acids with reactive oligonucleotide derivatives

FEBS Lett. 1988 Sep 26;238(1):35-8. doi: 10.1016/0014-5793(88)80220-5.

Authors

I V Kutyavin¹, M A Podyminogin, Bazhina YuN, O S Fedorova, D G Knorre, A S Levina, S V Mamayev, V F Zarytova

Affiliation

¹ Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Novosibirsk.

PMID: 3169251
DOI: 10.1016/0014-5793(88)80220-5

Abstract

It has been found that mono- and especially diphenazinium derivatives of oligonucleotides complementary to the DNA sequence adjacent to the target sequence of the addressed alkylation of DNA, significantly enhance the extent and specificity of alkylation with p-(N-2-chloroethyl-N-methylamino)benzylamide derivatives of the addressing oligonucleotides, thus playing the role of effector of the sequence-specific (complementary addressed) modification.

MeSH terms

Alkylation
Base Sequence
DNA, Single-Stranded / genetics*
Indicators and Reagents
Molecular Sequence Data
Oligonucleotide Probes / chemical synthesis*
Phenazines*
Structure-Activity Relationship

Substances

DNA, Single-Stranded
Indicators and Reagents
Oligonucleotide Probes
Phenazines