Muir-Torre Syndrome: The Importance of a Detailed Family History

Christopher K H Burris; Maria E Rodriguez; Meisha L Raven; Devasis N Reddy; Yaohui G Xu; Janey L Wiggs; Heather D Potter; Daniel M Albert

doi:10.1159/000500662

Muir-Torre Syndrome: The Importance of a Detailed Family History

Case Rep Ophthalmol. 2019 May 23;10(2):180-185. doi: 10.1159/000500662. eCollection 2019 May-Aug.

Authors

Christopher K H Burris¹, Maria E Rodriguez¹, Meisha L Raven¹, Devasis N Reddy¹, Yaohui G Xu², Janey L Wiggs³, Heather D Potter¹, Daniel M Albert⁴

Affiliations

¹ Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA.
² Department of Dermatology, University of Wisconsin, Madison, Wisconsin, USA.
³ Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.
⁴ Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA.

Abstract

Muir-Torre syndrome, a variant of Lynch syndrome or hereditary nonpolyposis colorectal cancer, is an autosomal dominant disease characterized by skin neoplasms (sebaceous or keratoacanthomas) and visceral malignancies. Due to the rarity of the syndrome there are no firm guidelines on how and when to test patients with its typical skin lesions. We describe a case that highlights the importance of a detailed family history.

Keywords: Lynch syndrome; Muir-Torre syndrome; Sebaceous carcinoma.

Publication types

Case Reports