Eight novel loci implicate shared genetic etiology in multiple myeloma, AL amyloidosis, and monoclonal gammopathy of unknown significance

Subhayan Chattopadhyay; Hauke Thomsen; Niels Weinhold; Iman Meziane; Stefanie Huhn; Miguel Inacio da Silva Filho; Pavel Vodicka; Ludmila Vodickova; Per Hoffmann; Markus M Nöthen; Karl-Heinz Jöckel; Börge Schmidt; Stefano Landi; Roman Hajek; Göran Hallmans; Ulrika Pettersson-Kymmer; Claes Ohlsson; Paolo Milani; Giampaolo Merlini; Dorota Rowcieno; Philip Hawkins; Ute Hegenbart; Giovanni Palladini; Ashutosh Wechalekar; Stefan O Schönland; Richard Houlston; Hartmut Goldschmidt; Kari Hemminki; Asta Försti

doi:10.1038/s41375-019-0619-1

Eight novel loci implicate shared genetic etiology in multiple myeloma, AL amyloidosis, and monoclonal gammopathy of unknown significance

Leukemia. 2020 Apr;34(4):1187-1191. doi: 10.1038/s41375-019-0619-1. Epub 2019 Nov 6.

Authors

Subhayan Chattopadhyay^{1

2}, Hauke Thomsen¹, Niels Weinhold³, Iman Meziane¹, Stefanie Huhn³, Miguel Inacio da Silva Filho¹, Pavel Vodicka^{4

5

6}, Ludmila Vodickova^{4

5

6}, Per Hoffmann^{7

8}, Markus M Nöthen^{7

9}, Karl-Heinz Jöckel¹⁰, Börge Schmidt¹⁰, Stefano Landi¹¹, Roman Hajek¹², Göran Hallmans¹³, Ulrika Pettersson-Kymmer¹⁴, Claes Ohlsson¹⁵, Paolo Milani¹⁶, Giampaolo Merlini¹⁶, Dorota Rowcieno¹⁷, Philip Hawkins¹⁷, Ute Hegenbart³, Giovanni Palladini¹⁶, Ashutosh Wechalekar¹⁷, Stefan O Schönland³, Richard Houlston^{18

19}, Hartmut Goldschmidt^{3

20}, Kari Hemminki^{1

2

6}, Asta Försti^{21

22

23}

Affiliations

¹ Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany.
² Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany.
³ Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
⁴ Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 00, Prague, Czech Republic.
⁵ Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University, Albertov 4, 128 00, Prague, Czech Republic.
⁶ Faculty of Medicine and Biomedical Center in Pilsen, Charles University in Prague, 30605, Pilsen, Czech Republic.
⁷ Institute of Human Genetics, University of Bonn, Bonn, Germany.
⁸ Department of Biomedicine, University of Basel, Basel, Switzerland.
⁹ Department of Genomics, Life & Brain Research Center, University of Bonn, Bonn, Germany.
¹⁰ Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
¹¹ Department of Biology, University of Pisa, Pisa, Italy.
¹² Department of Hematooncology, University Hospital Ostrava, 17. listopadu 1790, 708 52, Ostrava, Czech Republic.
¹³ Department of Medical Biosciences/Pathology, University of Umea, Umea, Sweden.
¹⁴ Clinical Pharmacology, Department of Pharmacology and Clinical Neuroscience, Umea University, Umea, Sweden.
¹⁵ Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
¹⁶ Amyloidosis Research and Treatment Center, Foundation "Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo" and Department of Molecular Medicine, University of Pavia, Pavia, Italy.
¹⁷ National Amyloidosis Centre, University College London Medical School, Royal Free Hospital Campus, London, Rowland Hill Street, London, NW32PF, UK.
¹⁸ Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK.
¹⁹ Division of Molecular Patholog, The Institute of Cancer Research, 15 Cotswold Road, Sutton, London, SM2 5NG, UK.
²⁰ National Centre of Tumor Diseases, Heidelberg, Germany.
²¹ Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany. [email protected].
²² Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany. [email protected].
²³ Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany. [email protected].

PMID: 31695157
DOI: 10.1038/s41375-019-0619-1

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers, Tumor / genetics*
Cohort Studies
Genetic Loci*
Genome-Wide Association Study / methods*
Humans
Immunoglobulin Light-chain Amyloidosis / etiology*
Immunoglobulin Light-chain Amyloidosis / pathology
Monoclonal Gammopathy of Undetermined Significance / etiology*
Monoclonal Gammopathy of Undetermined Significance / pathology
Multiple Myeloma / etiology*
Multiple Myeloma / pathology
Polymorphism, Single Nucleotide*
Prognosis

Substances

Biomarkers, Tumor