Cutaneous blastic plasmacytoid dendritic cell neoplasm arising in the context of TET2 and ZRSR2 mutated clonal cytopenias of unknown significance, secondary to somatic copy number losses involving CDK2NA/2NB and MTAP

Am J Hematol. 2020 Feb;95(2):E31-E34. doi: 10.1002/ajh.25675. Epub 2019 Dec 4.
No abstract available

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cyclin-Dependent Kinase Inhibitor p15* / genetics
  • Cyclin-Dependent Kinase Inhibitor p15* / metabolism
  • Cyclin-Dependent Kinase Inhibitor p16* / genetics
  • Cyclin-Dependent Kinase Inhibitor p16* / metabolism
  • DNA Copy Number Variations*
  • DNA-Binding Proteins* / genetics
  • DNA-Binding Proteins* / metabolism
  • Dendritic Cells* / metabolism
  • Dendritic Cells* / pathology
  • Dioxygenases
  • Humans
  • Male
  • Mutation*
  • Myeloproliferative Disorders* / genetics
  • Myeloproliferative Disorders* / metabolism
  • Myeloproliferative Disorders* / pathology
  • Proto-Oncogene Proteins* / genetics
  • Proto-Oncogene Proteins* / metabolism
  • Retinoblastoma Binding Proteins
  • Ribonucleoproteins* / genetics
  • Ribonucleoproteins* / metabolism
  • Skin Neoplasms* / genetics
  • Skin Neoplasms* / metabolism
  • Skin Neoplasms* / pathology
  • Ubiquitin-Protein Ligases

Substances

  • CDKN2A protein, human
  • CDKN2B protein, human
  • Cyclin-Dependent Kinase Inhibitor p15
  • Cyclin-Dependent Kinase Inhibitor p16
  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • RB1 protein, human
  • Retinoblastoma Binding Proteins
  • Ribonucleoproteins
  • ZRSR2 protein, human
  • Dioxygenases
  • TET2 protein, human
  • Ubiquitin-Protein Ligases

Grants and funding