Abstract
The amelioration of antibacterial efficacy along with the reduced minimum inhibitory concentration (MIC) of sanguinarine (SGR) drug have been demonstrated through the uptake of SGR by p-sulfonatocalix[6]arene functionalized silver nanoparticles. The large upward pKa shift and enhanced stability of SGR resulting from the favorable supra-nanomolecular strategy are deciphered into an improved antibacterial drug against different pathogenic micro-organisms including multi drug resistant bacteria.
MeSH terms
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A549 Cells
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Benzophenanthridines / chemistry
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Benzophenanthridines / pharmacology*
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CHO Cells
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Calixarenes / chemistry*
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Cell Survival / drug effects
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Cricetulus
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Drug Synergism
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Escherichia coli / drug effects*
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Humans
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Isoquinolines / chemistry
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Isoquinolines / pharmacology*
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Metal Nanoparticles / chemistry*
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Microbial Sensitivity Tests
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Particle Size
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Phenols / chemistry*
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Silver / chemistry*
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Staphylococcus aureus / drug effects*
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Surface Properties
Substances
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Anti-Bacterial Agents
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Benzophenanthridines
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Isoquinolines
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Phenols
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calix(6)arene
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Calixarenes
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Silver
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sanguinarine