Isoprenoid (phosphinylmethyl)phosphonates as inhibitors of squalene synthetase

J Med Chem. 1988 Oct;31(10):1869-71. doi: 10.1021/jm00118a001.
No abstract available

MeSH terms

  • Animals
  • Diphosphonates / pharmacology*
  • Farnesyl-Diphosphate Farnesyltransferase / antagonists & inhibitors*
  • Kinetics
  • Microsomes, Liver / enzymology
  • Organophosphorus Compounds / pharmacology*
  • Oxidoreductases / antagonists & inhibitors*
  • Polyisoprenyl Phosphates / pharmacology*
  • Rats
  • Sesquiterpenes
  • Terpenes / pharmacology*

Substances

  • Diphosphonates
  • Organophosphorus Compounds
  • Polyisoprenyl Phosphates
  • Sesquiterpenes
  • Terpenes
  • farnesyl pyrophosphate
  • Oxidoreductases
  • Farnesyl-Diphosphate Farnesyltransferase