Abstract
Primary mediastinal large B-cell lymphoma (PMLBCL) is an aggressive lymphoma characteristic with distinct clinical, morphologic, and immunophenotypic features. The rearrangements of C-MYC, BCL2 and/or BCL6 which are common in diffuse large B-cell lymphoma (DLBCL) are typically absent in PLMBCL. Here we proved a novel case of PMLBCL with concurrent rearrangements of C-MYC and BCL2. Histology showed typical pathomorphological features of PLMBCL. Fluorescent in situ hybridization (FISH) studies showed rearrangements of C-MYC and copy number variation (CNV) of BCL2 gene. It is not well known on the clinical significance of rearrangements of C-MYC and BCL2 genes in PMLBCL. The case gives evidence that cytogenetic testing is necessary for PMLBCLs to get precise clinical evaluation and appropriate treatment.
Keywords:
BCL2; C-MYC; Copy number variation; Gene rearrangement; Primary mediastinal large B-cell lymphoma.
MeSH terms
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
-
Biopsy, Large-Core Needle
-
Combined Modality Therapy / methods
-
DNA Copy Number Variations
-
Gene Rearrangement
-
Humans
-
Lung Neoplasms / diagnosis
-
Lung Neoplasms / genetics*
-
Lung Neoplasms / secondary
-
Lung Neoplasms / therapy
-
Lymphoma, Large B-Cell, Diffuse / diagnosis
-
Lymphoma, Large B-Cell, Diffuse / genetics*
-
Lymphoma, Large B-Cell, Diffuse / pathology
-
Lymphoma, Large B-Cell, Diffuse / therapy
-
Male
-
Mediastinal Neoplasms / diagnosis
-
Mediastinal Neoplasms / genetics*
-
Mediastinal Neoplasms / pathology
-
Mediastinal Neoplasms / therapy
-
Mediastinum / diagnostic imaging
-
Mediastinum / pathology
-
Positron Emission Tomography Computed Tomography
-
Proto-Oncogene Proteins c-bcl-2
-
Proto-Oncogene Proteins c-myc
-
Stem Cell Transplantation*
-
Transplantation, Autologous
-
Treatment Outcome
-
Young Adult
Substances
-
BCL2 protein, human
-
MYC protein, human
-
Proto-Oncogene Proteins c-bcl-2
-
Proto-Oncogene Proteins c-myc