Combinatorial Oxytocin Neuropharmacology in Social Cognition

Siqi Fan; Hannah Weinberg-Wolf; Matthew Piva; Olga Dal Monte; Steve W C Chang

doi:10.1016/j.tics.2019.10.004

Combinatorial Oxytocin Neuropharmacology in Social Cognition

Trends Cogn Sci. 2020 Jan;24(1):8-12. doi: 10.1016/j.tics.2019.10.004. Epub 2019 Nov 14.

Authors

Siqi Fan¹, Hannah Weinberg-Wolf¹, Matthew Piva¹, Olga Dal Monte², Steve W C Chang³

Affiliations

¹ Department of Psychology, Yale University, New Haven, CT, USA.
² Department of Psychology, Yale University, New Haven, CT, USA; Department of Psychology, University of Turin, Torino, Italy.
³ Department of Psychology, Yale University, New Haven, CT, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT, USA. Electronic address: [email protected].

PMID: 31735541
DOI: 10.1016/j.tics.2019.10.004

Abstract

The efficacy and reliability of using intranasal oxytocin (OT) to clinically enhance social functions remains undependable. We discuss the potential benefit of concurrent administration of OT and naloxone (NAL) to robustly modulate social behavior. We further suggest that combinatorial neuropharmacology approaches should exploit the interactions between OT and serotonin to regulate social functions.

Keywords: autism spectrum disorders; combinatorial neuropharmacology; naloxone; oxytocin; serotonin.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Autism Spectrum Disorder / therapy
Humans
Neuropharmacology*
Oxytocin / administration & dosage
Oxytocin / therapeutic use*
Reproducibility of Results
Social Behavior*
Social Cognition*

Substances

Oxytocin

Abstract

Publication types

MeSH terms

Substances

Grants and funding