Fine-needle aspiration cytology of extra-salivary adenoid cystic carcinoma

Cytopathology. 2020 May;31(3):215-222. doi: 10.1111/cyt.12789. Epub 2019 Dec 25.

Abstract

Introduction: Adenoid cystic carcinoma (ACC) is a ubiquitous tumour which can occur in several sites of the human body. Commonly, it affects the salivary glands but also can rarely occur in various extra-salivary locations.

Aim: To study the clinical and cytological features of extra-salivary ACC on fine needle aspiration cytology.

Methods: In this paper, we included 27 patients with extra-salivary ACC on fine needle aspiration cytology over a period of 5.5 years. The complete cytomorphological spectrum of extra-salivary ACC was studied.

Results: The mean age of the patients was 50.2 years, with age ranging between 14 and 80 years. Male to female ratio was 1:1.7 with 17 females and 10 males. The most frequent primary site was the orbit, and the most frequent sites of metastasis were liver and lung.

Conclusion: Cytopathologists should be alert about the full range of location as well as the cytological spectrum of extra-salivary ACC for greater precision in diagnosis and prompt treatment.

Keywords: adenoid cystic carcinoma; fine-needle aspiration cytology.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Biopsy, Fine-Needle / methods
  • Carcinoma, Adenoid Cystic / diagnosis*
  • Carcinoma, Adenoid Cystic / pathology*
  • Cytodiagnosis / methods
  • Cytological Techniques / methods
  • Diagnosis, Differential
  • Female
  • Humans
  • Liver Neoplasms / pathology
  • Lung Neoplasms / pathology
  • Male
  • Middle Aged
  • Salivary Gland Neoplasms / diagnosis*
  • Salivary Gland Neoplasms / pathology*
  • Salivary Glands / diagnostic imaging*
  • Salivary Glands / pathology*