T Cell Metabolism in a State of Flux

Siva Karthik Varanasi; Shixin Ma; Susan M Kaech

doi:10.1016/j.immuni.2019.10.012

T Cell Metabolism in a State of Flux

Immunity. 2019 Nov 19;51(5):783-785. doi: 10.1016/j.immuni.2019.10.012.

Authors

Siva Karthik Varanasi¹, Shixin Ma¹, Susan M Kaech²

Affiliations

¹ NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA.
² NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA. Electronic address: [email protected].

PMID: 31747577
DOI: 10.1016/j.immuni.2019.10.012

Abstract

Our knowledge of T cell metabolism relies primarily on studies performed in vitro that may not fully recapitulate physiological conditions in vivo. In this issue of Immunity, Ma et al. find that the in vivo environment dictates the metabolic phenotype of effector CD8+ T cells-particularly their glucose utilization.

Publication types

Comment

MeSH terms

CD8-Positive T-Lymphocytes*
Glucose*
Isotopes
Metabolomics
Phenotype

Substances

Isotopes
Glucose