Biological intratumoral therapy for the high-grade glioma part I: intratumoral delivery and immunotoxins

CNS Oncol. 2019 Nov 1;8(3):CNS38. doi: 10.2217/cns-2019-0001. Epub 2019 Nov 21.

Abstract

Management of high-grade gliomas remains a complex challenge. Standard of care consists of microsurgical resection, chemotherapy and radiation, but despite these aggressive multimodality therapies the overall prognosis remains poor. A major focus of ongoing translational research studies is to develop novel therapeutic strategies that can maximize tumor cell eradication while minimizing collateral side effects. Particularly, biological intratumoral therapies have been the focus of new translational research efforts due to their inherent potential to be both dynamically adaptive and target specific. This two-part review will provide an overview of biological intratumoral therapies and summarize key advances and remaining challenges in intratumoral biological therapies for high-grade glioma. Part I focuses on discussion of the concepts of intratumoral delivery and immunotoxin therapies.

Keywords: biologic therapy; brain neoplasm; chemotherapy; drug delivery; glioblastoma; high-grade gliomas; immunotoxin; intratumoral delivery.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / immunology
  • Antineoplastic Agents / therapeutic use*
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / immunology
  • Brain Neoplasms / pathology
  • Drug Delivery Systems
  • Glioma / drug therapy*
  • Glioma / pathology
  • Humans
  • Immunotoxins / immunology
  • Immunotoxins / therapeutic use*
  • Infusions, Intralesional
  • Injections, Intralesional
  • Neoplasm Grading
  • Prognosis
  • Randomized Controlled Trials as Topic

Substances

  • Antineoplastic Agents
  • Immunotoxins