Nanoscale Location Matters: Emerging Principles of Ca2+ Channel Organization at the Presynaptic Active Zone

Changliang Liu; Pascal S Kaeser

doi:10.1016/j.neuron.2019.10.015

Nanoscale Location Matters: Emerging Principles of Ca²⁺ Channel Organization at the Presynaptic Active Zone

Neuron. 2019 Nov 20;104(4):627-629. doi: 10.1016/j.neuron.2019.10.015.

Authors

Changliang Liu¹, Pascal S Kaeser²

Affiliations

¹ Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
² Department of Neurobiology, Harvard Medical School, Boston, MA, USA. Electronic address: [email protected].

PMID: 31751541
DOI: 10.1016/j.neuron.2019.10.015

Abstract

How does diversity in the organization of secretory machines determine properties of neurotransmitter release? In this issue of Neuron, Rebola et al. (2019) found that distinct nanoscale assemblies of Ca²⁺ channels and Munc13, not overall channel abundance, mediate differing release characteristics of two cerebellar synapses.

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Comment

MeSH terms

Calcium
Calcium Channels*
Synapses
Synaptic Transmission
Synaptic Vesicles*

Substances

Calcium Channels
Calcium

Abstract

Publication types

MeSH terms

Substances

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