Sleep disordered breathing (SDB) in neonates and implications for its long-term impact

Bhavesh Mehta; Karen Waters; Dominic Fitzgerald; Nadia Badawi

doi:10.1016/j.prrv.2019.10.003

Sleep disordered breathing (SDB) in neonates and implications for its long-term impact

Paediatr Respir Rev. 2020 Apr:34:3-8. doi: 10.1016/j.prrv.2019.10.003. Epub 2019 Oct 30.

Authors

Bhavesh Mehta¹, Karen Waters², Dominic Fitzgerald², Nadia Badawi³

Affiliations

¹ Department of Neonatology, The Children's Hospital at Westmead, Sydney, NSW, Australia; Discipline of Paediatrics & Child Health, Sydney Medical School, University of Sydney, Australia. Electronic address: [email protected].
² Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, NSW, Australia; Discipline of Paediatrics & Child Health, Sydney Medical School, University of Sydney, Australia.
³ Department of Neonatology, The Children's Hospital at Westmead, Sydney, NSW, Australia; Discipline of Paediatrics & Child Health, Sydney Medical School, University of Sydney, Australia; Cerebral Palsy Research Institute, Brain and Mind Institute, Sydney, Australia.

PMID: 31753754
DOI: 10.1016/j.prrv.2019.10.003

Abstract

Sleep-disordered breathing (SDB) is a significant cause of morbidity in neonates and young infants. SDB occurs more commonly in preterm infants and in neonates with underlying syndromes. Recent evidence shows that infants with obstructive sleep apnoea (OSA) or SDB have greater health care resource utilization, including longer hospital stay. Management of SDB includes non-invasive ventilation or surgical interventions tailored to the patient. Screening high risk newborns should allow for early diagnosis and timely therapeutic intervention for this population. However, the thresholds for diagnosing SDB and for guiding and implementing treatment in neonates remain unclear. A collective effort is required to standardize the practice worldwide. This article will discuss neonatal sleep physiology and characteristics of neonatal sleep, with an emphasis on the epidemiology and diagnosis of SDB in neonates and its implications for long term outcomes.

Keywords: Neurodevelopmental outcome; Newborn; Obstructive sleep apnoea; Sleep; Sleep disordered breathing.

Publication types

Review

MeSH terms

Humans
Hypoventilation / diagnosis
Hypoventilation / epidemiology
Hypoventilation / physiopathology
Hypoventilation / therapy
Infant
Infant, Newborn
Infant, Premature
Length of Stay
Mass Screening
Noninvasive Ventilation
Prognosis
Respiration
Risk Factors
Sleep / physiology
Sleep Apnea Syndromes / diagnosis
Sleep Apnea Syndromes / epidemiology*
Sleep Apnea Syndromes / physiopathology
Sleep Apnea Syndromes / therapy
Sleep Apnea, Central / diagnosis
Sleep Apnea, Central / epidemiology
Sleep Apnea, Central / physiopathology
Sleep Apnea, Central / therapy
Sleep Apnea, Obstructive / diagnosis
Sleep Apnea, Obstructive / epidemiology
Sleep Apnea, Obstructive / physiopathology
Sleep Apnea, Obstructive / therapy