Abstract
Combining 2D STD-NMR, computation, biochemical assays and click-chemistry, we have identified a chromogranin-A derived compound (5) that has high affinity and bi-selectivity for αvβ6 and αvβ8 integrins and is stable in microsomal preparations. 5 is suitable for nanoparticle functionalization and delivery to cancer cells, holding promise for diagnostic and/or therapeutic applications.
MeSH terms
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Amino Acid Sequence
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Antigens, Neoplasm / metabolism*
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Cell Line, Tumor
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Chromogranin A / chemistry*
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Humans
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Integrins / antagonists & inhibitors
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Integrins / metabolism*
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Ligands
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Microscopy, Fluorescence
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Nuclear Magnetic Resonance, Biomolecular
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Peptides / chemistry
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Peptides / metabolism*
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Protein Binding
Substances
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Antigens, Neoplasm
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Chromogranin A
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Integrins
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Ligands
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Peptides
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integrin alphavbeta6
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integrin alphavbeta8