Autonomic Cross-Innervation in Patients With Neurofibromatosis Type 2: Frey Syndrome and Unilateral Epiphora With Rhinorrhea

Erica Evans; David Nascene; Katherine Sommer; Christopher Moertel

doi:10.1177/2329048X19866617

Autonomic Cross-Innervation in Patients With Neurofibromatosis Type 2: Frey Syndrome and Unilateral Epiphora With Rhinorrhea

Child Neurol Open. 2019 Aug 6:6:2329048X19866617. doi: 10.1177/2329048X19866617. eCollection 2019.

Authors

Erica Evans¹, David Nascene², Katherine Sommer³, Christopher Moertel³

Affiliations

¹ University of Minnesota Medical School, Minneapolis, MN, USA.
² Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, USA.
³ Pediatric Hematology-Oncology, Department of Pediatrics, University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA.

Abstract

The authors present 2 cases of cross-innervation in patients with neurofibromatosis type 2. In the first case, an iodine test was performed to demonstrate Frey syndrome in a 28-year-old female with neurofibromatosis type 2 who developed symptoms at age 10 years. The second patient is an 18-year-old female with neurofibromatosis type 2, 2 years status post left vestibular schwannoma subtotal resection who presented with paradoxical unilateral lacrimation and rhinorrhea triggered by heat stress and exercise. The pathophysiology of these cases is discussed.

Keywords: auriculotemporal nerve syndrome; nervus intermedius; neurofibromatosis type 2; paradoxical lacrimation and rhinorrhea; vestibular schwannoma.

Publication types

Case Reports