Tubercular Uveitis: Nuggets from Collaborative Ocular Tuberculosis Study (COTS)-1

Ilaria Testi; Rupesh Agrawal; Sarakshi Mahajan; Aniruddha Agarwal; Dinesh Visva Gunasekeran; Dhananjay Raje; Kanika Aggarwal; Somasheila I Murthy; Mark Westcott; Soon Phaik Chee; Peter McCluskey; Su Ling Ho; Stephen Teoh; Luca Cimino; Jyotirmay Biswas; Shishir Narain; Manisha Agarwal; Padmamalini Mahendradas; Moncef Khairallah; Nicholas Jones; Ilknur Tugal-Tutkun; Kalpana Babu; Soumayava Basu; Ester Carreño; Richard Lee; Hassan Al-Dhibi; Bahram Bodaghi; Alessandro Invernizzi; Debra A Goldstein; Carl P Herbort; Talin Barisani-Asenbauer; Julio J González-López; Sofia Androudi; Reema Bansal; Bruttendu Moharana; Simona Degli Esposti; Anastasia Tasiopoulou; Sengal Nadarajah; Mamta Agarwal; Sharanya Abraham; Ruchi Vala; Ramandeep Singh; Aman Sharma; Kusum Sharma; Manfred Zierhut; Andres Rousselot; Robert Grant; Onn Min Kon; Emmett T Cunningham; John Kempen; Quan Dong Nguyen; Carlos Pavesio; Vishali Gupta

doi:10.1080/09273948.2019.1646774

Tubercular Uveitis: Nuggets from Collaborative Ocular Tuberculosis Study (COTS)-1

Ocul Immunol Inflamm. 2020 Sep 30;28(sup1):8-16. doi: 10.1080/09273948.2019.1646774. Epub 2019 Nov 25.

Authors

Ilaria Testi¹, Rupesh Agrawal^{2

3

4}, Sarakshi Mahajan⁵, Aniruddha Agarwal⁶, Dinesh Visva Gunasekeran^{2

3}, Dhananjay Raje⁷, Kanika Aggarwal⁶, Somasheila I Murthy⁸, Mark Westcott¹, Soon Phaik Chee^{4

9}, Peter McCluskey¹⁰, Su Ling Ho², Stephen Teoh², Luca Cimino¹¹, Jyotirmay Biswas¹², Shishir Narain¹³, Manisha Agarwal¹⁴, Padmamalini Mahendradas¹⁵, Moncef Khairallah¹⁶, Nicholas Jones¹⁷, Ilknur Tugal-Tutkun¹⁸, Kalpana Babu¹⁹, Soumayava Basu²⁰, Ester Carreño²¹, Richard Lee²², Hassan Al-Dhibi²³, Bahram Bodaghi²⁴, Alessandro Invernizzi²⁵, Debra A Goldstein²⁶, Carl P Herbort²⁷, Talin Barisani-Asenbauer²⁸, Julio J González-López²⁹, Sofia Androudi³⁰, Reema Bansal⁶, Bruttendu Moharana⁶, Simona Degli Esposti³, Anastasia Tasiopoulou¹, Sengal Nadarajah¹, Mamta Agarwal¹², Sharanya Abraham¹², Ruchi Vala¹⁵, Ramandeep Singh⁶, Aman Sharma³¹, Kusum Sharma³², Manfred Zierhut³³, Andres Rousselot³⁴, Robert Grant³⁵, Onn Min Kon³⁶, Emmett T Cunningham³⁷, John Kempen^{38

39}, Quan Dong Nguyen⁵, Carlos Pavesio¹, Vishali Gupta⁶

Affiliations

¹ Moorfields Eye Hospital, NHS Foundation Trust, London, UK.
² National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore.
³ School of Material Science and Engineering, Nanyang Technological University, Singapore, Singapore.
⁴ Singapore Eye Research Institute, Singapore, Singapore.
⁵ Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
⁶ Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
⁷ MDS Bioanalytics, Nagpur, India.
⁸ Tej Kohli Cornea Institute, LV Prasad Eye Institute, Hyderabad, India.
⁹ Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
¹⁰ Department of Clinical Ophthalmology & Eye Health, Central Clinical School, Save Sight Institute, The University of Sydney, Sydney, Australia.
¹¹ Ocular Immunology Unit, Azienda USL IRCCS, Reggio Emilia, Italy.
¹² Department of Ophthalmology, Sankara Nethralaya, Chennai, India.
¹³ Department of Ophthalmology, Shroff Eye Centre, New Delhi, India.
¹⁴ Department of Ophthalmology, Dr Shroff's Charity Eye Hospital Daryaganj, New Delhi, India.
¹⁵ Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bangalore, India.
¹⁶ Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia.
¹⁷ Department of Ophthalmology, University of Manchester, Manchester, UK.
¹⁸ Istanbul Faculty of Medicine, Department of Ophthalmology, Istanbul University, Instanbul, Turkey.
¹⁹ Prabha Eye Clinic & Research Centre, Vittala International Institute of Ophthalmology, Bangalore, India.
²⁰ Department of Ophthalmology, LV Prasad Eye Institute, Bhubaneswar, India.
²¹ Departamento de Oftalmología, Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain.
²² Department of Ophthalmology, Bristol Eye Hospital, Bristol, UK.
²³ Department of Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia.
²⁴ DHU SightRestore, Department of Ophthalmology, Sorbonne University, Paris, France.
²⁵ Eye Clinic, Department of Biomedical and Clinical Science "L. Sacco", Luigi Sacco Hospital, University of Milan, Milan, Italy.
²⁶ Feinberg School of Medicine, Department of Ophthalmology, Northwestern University, Chicago, IL, USA.
²⁷ Centre for Ophthalmic Specialised Care, University of Lausanne, Lausanne, Switzerland.
²⁸ The Centre for Ocular Inflammation and Infection (OCUVAC), Laura Bassi Centre of Expertise Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
²⁹ Department of Ophthalmology, Ramón y Cajal University Hospital, Madrid, Spain.
³⁰ Department of Ophthalmology, University of Thessaly, Larissa, Greece.
³¹ Department of Rheumatology, PGIMER, Chandigarh, India.
³² Department of Microbiology, PGIMER, Chandigarh, India.
³³ Centre of Ophthalmology, Department of Ophthalmology, University of Tuebingen, Tuebingen, Germany.
³⁴ Department of Ophthalmology, Universidad del Salvador of Buenos Aires, Buenos Aires, Argentina.
³⁵ Faculty of Health, Social Care and Education, Kingston University and St George's, University of London, London, UK.
³⁶ Chest and Allergy Clinic, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK.
³⁷ The Francis I. Proctor Foundation, UCSF School of Medicine, San Francisco, California, USA.
³⁸ Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
³⁹ MCM Eye Unit, MyungSung Christian Medical Center and MyungSung Medical School, Addis Ababa, Ethiopia.

PMID: 31763952
DOI: 10.1080/09273948.2019.1646774

Abstract

Background: Tuberculosis (TB) is a major infection that can affect the eye as first and sole presentation without features of systemic disease. Controversy exists regarding diagnosis and management of tubercular uveitis (TBU), further compounded by regional variations in disease expression. Purpose: Collaborative Ocular Tuberculosis Study (COTS)-1 aims to address knowledge deficits through collaboration amongst uveitis specialists across the globe by sharing the data of patients with TBU presented at participating centers from January 2004 to December 2014. Methods: Data collection was facilitated by a novel method of real-time encrypted web-based data entry allowing regular updates as new data and recommendations become available. Results: Information on clinical features, investigation findings, management, and treatment outcomes were reviewed to get an idea about real world scenario. Conclusion: The current review aims to focus on methodology and briefing of published reports from COTS group in COTS-1 study to highlight key messages from this large data.

Keywords: Anti-tubercular therapy; Collaborative Ocular Tuberculosis Study (COTS); choroiditis; global experts; tubercular uveitis; tuberculosis.