Piperacillin-tazobactam should be preferred to third-generation cephalosporins to treat wild-type inducible AmpC-producing Enterobacterales in critically ill patients with hospital or ventilator-acquired pneumonia

J Crit Care. 2020 Apr:56:6-11. doi: 10.1016/j.jcrc.2019.11.005. Epub 2019 Nov 13.

Abstract

Purpose: To compare the rate of therapeutic failure in critically ill patients treated by third-generation cephalosporins (3GCs) or piperacillin-tazobactam (PTZ) for wild-type AmpC-producing Enterobacterales pulmonary infections.

Methods: Over a 4-year period, all adult patients treated for a wild-type AmpC-producing Enterobacterales pulmonary infection were retrospectively included. Two groups of patients were compared according to the definitive antibiotic therapy (3GCs or PTZ) considered after <48 h of empirical antibiotic therapy. The main outcome was the rate of therapeutic failure (impaired clinical response under treatment and/or a relapse of pulmonary infection). The secondary outcome was a secondary acquisition of 3GCs resistance.

Results: Over the study period, 244 patients were included; 56 (23%) experienced therapeutic failure. In the non-adjusted cohort, the rate of therapeutic failure and emergence of resistance were significantly higher in the 3GCs group (32 vs. 18%, p = .011 and 13 vs. 5%, p = .035, respectively). In the propensity score-matched population, the use of 3GCs was associated with higher rates of therapeutic failure (HR = 1.61 [1.27-2.07]). The secondary de-escalation to 3GCs after 48 h of PTZ as a first-line antibiotic therapy was not associated with increased rate of emergence of resistance.

Conclusion: Our study confirms that 3GCs should be avoided as first-line antibiotic therapy in wild-type AmpC-producing Enterobacterales pulmonary infections.

Keywords: Enterobacterales; Intensive care; Piperacillin-tazobactam; Pneumonia; Third-generation cephalosporins.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Anti-Bacterial Agents / therapeutic use
  • Bacterial Proteins / metabolism*
  • Cephalosporins / therapeutic use*
  • Critical Illness*
  • Cross Infection / drug therapy*
  • Enterobacter
  • Family Characteristics
  • Female
  • Hospitals
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / drug therapy
  • Penicillanic Acid
  • Piperacillin, Tazobactam Drug Combination / therapeutic use*
  • Pneumonia, Ventilator-Associated / drug therapy*
  • Retrospective Studies
  • Ventilators, Mechanical
  • beta-Lactamases / metabolism*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Cephalosporins
  • Piperacillin, Tazobactam Drug Combination
  • Penicillanic Acid
  • AmpC beta-lactamases
  • beta-Lactamases