Abstract
Human adenovirus commonly causes infections of respiratory, gastrointestinal, genitourinary, and ocular surface mucosae. Although most adenovirus eye infections are mild and self-limited, specific viruses within human adenovirus species D are associated with epidemic keratoconjunctivitis (EKC), a severe and highly contagious ocular surface infection, which can lead to chronic and/or recurrent, visually disabling keratitis. In this review, we discuss the links between adenovirus ontogeny, genomics, immune responses, and corneal pathogenesis, for those viruses that cause EKC.
Keywords:
conjunctivitis; epidemic keratoconjunctivitis; genomics; homologous recombination; human adenovirus; inflammation; ocular infection; pink eye; tropism; virus evolution.
© 2019 Federation of European Biochemical Societies.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adenoviruses, Human / genetics
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Adenoviruses, Human / immunology
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Adenoviruses, Human / pathogenicity*
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Animals
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Biological Evolution*
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Conjunctiva / immunology
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Conjunctiva / metabolism
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Conjunctiva / pathology
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Conjunctiva / virology
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Cornea / immunology
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Cornea / metabolism
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Cornea / pathology
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Cornea / virology
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Disease Models, Animal
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Eye Proteins / genetics*
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Eye Proteins / immunology
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Gene Expression Regulation
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Genomics / methods
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Host-Pathogen Interactions / genetics*
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Host-Pathogen Interactions / immunology
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Humans
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Immunity, Innate
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Keratitis / genetics*
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Keratitis / immunology
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Keratitis / pathology
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Keratitis / virology
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Keratoconjunctivitis / genetics*
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Keratoconjunctivitis / immunology
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Keratoconjunctivitis / pathology
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Keratoconjunctivitis / virology
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Phylogeny
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Viral Proteins / genetics*
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Viral Proteins / immunology
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Viral Tropism / genetics
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Viral Tropism / immunology
Substances
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Eye Proteins
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Viral Proteins