Abstract
The authors investigated the immunological and pharmacological activity of l-cysteine hydrazide. It was found, that the preparation exhibited an interesting immunosuppressive and anti-inflammatory effect, which was evoked by the interference of the drug in nucleic acids and by stabilization of the cell membranes. Moreover it diminished the number of T lymphocytes. L-cysteine hydrazide showed no significant side effects. The authors discussed the possibility of its application in clinical therapy.
MeSH terms
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Analgesia
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Animals
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Anti-Inflammatory Agents, Non-Steroidal
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Arthritis, Experimental / drug therapy
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Cysteine / analogs & derivatives*
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Cysteine / immunology
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Cysteine / toxicity
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Dogs
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Guinea Pigs
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Hemodynamics / drug effects
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Immunity, Cellular / drug effects
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Immunosuppressive Agents* / pharmacology
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Immunosuppressive Agents* / toxicity
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Mice
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Muscle, Smooth / drug effects
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Rabbits
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Rats
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Respiration / drug effects
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Immunosuppressive Agents
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cysteine hydrazide
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Cysteine