Nickel-Catalyzed Electrochemical Reductive Relay Cross-Coupling of Alkyl Halides to Aryl Halides

Ke-Jin Jiao; Dong Liu; Hong-Xing Ma; Hui Qiu; Ping Fang; Tian-Sheng Mei

doi:10.1002/anie.201912753

Nickel-Catalyzed Electrochemical Reductive Relay Cross-Coupling of Alkyl Halides to Aryl Halides

Angew Chem Int Ed Engl. 2020 Apr 16;59(16):6520-6524. doi: 10.1002/anie.201912753. Epub 2019 Dec 30.

Authors

Ke-Jin Jiao¹, Dong Liu¹, Hong-Xing Ma^{1

2}, Hui Qiu¹, Ping Fang¹, Tian-Sheng Mei¹

Affiliations

¹ State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
² School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng, 224051, China.

PMID: 31793156
DOI: 10.1002/anie.201912753

Abstract

A highly regioselective Ni-catalyzed electrochemical reductive relay cross-coupling between an aryl halide and an alkyl halide has been developed in an undivided cell. Various functional groups are tolerated under these mild reaction conditions, which provides an alternative approach for the synthesis of 1,1-diarylalkanes.

Keywords: arenes; cross-coupling; electrochemistry; nickel; reaction mechanisms.

Abstract

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