Unbiased screening reveals that blocking exportin 1 overcomes resistance to PI3Kα inhibition in breast cancer

Signal Transduct Target Ther. 2019 Nov 22:4:49. doi: 10.1038/s41392-019-0085-2. eCollection 2019.

Xue-Ling Liu^#^{1

2}, Bo-Bo Wang^#^{1

3}, Yi Wang¹, Yu-Xiang Wang^{1

4}, Chun-Hao Yang⁵, Cun Tan⁵, Xi Zhang¹, Qiao-Jun He³, Jian Ding^{4

6}, Ling-Hua Meng^{1

4}

¹ 1Division of Anti-Tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203 China.
² 2Zhejiang Province Key Laboratory for Drug Evaluation and Clinical Research, First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003 China.
³ 3Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058 China.
⁴ 4University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049 China.
⁵ 5Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203 China.
⁶ 6Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203 China.

^# Contributed equally.

No abstract available

Keywords: Breast cancer; Drug screening.