Non-ischemic Cardiomyopathy: Role of Immunologic Work-up and Cardiac MRI in Etiologic Diagnosis and Outcomes

Objective: Study etiology of Non ischemic cardiomyopathy (NICMP) and role of cardiac MRI in diagnosis and outcomes.

Methods: prospective observational study.

Inclusion criteria: 1. Clinical feature of cardiac failure, 2. 2D ECHO Systolic dysfunction, EF <45% OR Diastolic dysfunction without regional wall motion abnormality, 3. Absent ischemic changes on ECG and/ or coronary angiography. Exclusion: Valvular & congenital heart disease, Cor pulmonale, Renal failure. Patient were subjected to CBC with absolute eosinophil count(AEC), ESR, Urine-r/m, NT-Pro-BNP, ANA, ANCA, ACE, Bone marrow, Amyloid fat pad biopsy etc., chest x ray, 2DE. HRCT Chest and coronary angiography, Cardiac MRI by 3 tesla MRI machine. Patients were treated with antic-failure drugs & as per etiology and followed at 6wk clinically (NYHA) and 2DE.

Result: forty four Patients, mean age 36 yrs F: M(22:22), many patients had feature other than cardiac failure like Raynaud's.