Genetic Variation Shapes Murine Gut Microbiota via Immunity

Emily R Davenport

doi:10.1016/j.it.2019.11.009

Genetic Variation Shapes Murine Gut Microbiota via Immunity

Trends Immunol. 2020 Jan;41(1):1-3. doi: 10.1016/j.it.2019.11.009. Epub 2019 Dec 3.

Author

Emily R Davenport¹

Affiliation

¹ Department of Biology, Huck Institutes of the Life Sciences, Institute for Computational and Data Sciences, Pennsylvania State University, University Park, PA 16802, USA. Electronic address: [email protected].

PMID: 31806285
DOI: 10.1016/j.it.2019.11.009

Abstract

Host genetics influence gut microbiome composition. However, determining the specific physiological mechanisms and microbes affected has been difficult due to 'cage' and 'legacy' effects in model systems. Recently, Khan et al. cleverly colonized ex-germ-free mice to demonstrate that immune genes regulate select bacterial lineages in the mouse gut.

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MeSH terms

Animals
Bacteria / genetics
Gastrointestinal Microbiome*
Genetic Variation
Humans
Immunity / genetics
Mice
Symbiosis